Definition of an Indoor Air Sampling Strategy for SARS-CoV-2 Detection and Risk Management: Case Study in Kindergartens.

In the last two years, the world has been overwhelmed by SARS-CoV-2. One of the most important ways to prevent the spread of the virus is the control of indoor conditions: from surface hygiene to ventilation. Regarding the indoor environments, monitoring the presence of the virus in the indoor air seems to be promising, since there is strong evidence that airborne transmission through infected droplets and aerosols is its dominant transmission route. So far, few studies report the successful detection of SARS-CoV-2 in the air; moreover, the lack of a standard guideline for air monitoring reduces the uniformity of the results and their usefulness in the management of the risk of virus transmission. In this work, starting from a critical analysis of the existing standards and guidelines for indoor air quality, we define a strategy to set-up indoor air sampling plans for the detection of SARS-CoV-2. The strategy is then tested through a case study conducted in two kindergartens in the metropolitan city of Milan, in Italy, involving a total of 290 children and 47 teachers from 19 classrooms. The results proved its completeness, effectiveness, and suitability as a key tool in the airborne SARS-CoV-2 infection risk management process. Future research directions are then identified and discussed.

Big Events theory and measures may help explain emerging long-term effects of current crises.

Big Events are periods during which abnormal large-scale events like war, economic collapse, revolts, or pandemics disrupt daily life and expectations about the future. They can lead to rapid change in health-related norms, beliefs, social networks and behavioural practices. The world is undergoing such Big Events through the interaction of COVID-19, a large economic downturn, massive social unrest in many countries, and ever-worsening effects of global climate change. Previous research, mainly on HIV/AIDS, suggests that the health effects of Big Events can be profound, but are contingent: Sometimes Big Events led to enormous outbreaks of HIV and associated diseases and conditions such as injection drug use, sex trading, and tuberculosis, but in other circumstances, Big Events did not do so. This paper discusses and presents hypotheses about pathways through which the current Big Events might lead to better or worse short and long term outcomes for various health conditions and diseases; considers how pre-existing societal conditions and changing 'pathway' variables can influence the impact of Big Events; discusses how to measure these pathways; and suggests ways in which research and surveillance might be conducted to improve human capacity to prevent or mitigate the effects of Big Events on human health.

Wearable Devices for Ergonomics: A Systematic Literature Review.

Wearable devices are pervasive solutions for increasing work efficiency, improving workers' well-being, and creating interactions between users and the environment anytime and anywhere. Although several studies on their use in various fields have been performed, there are no systematic reviews on their utilisation in ergonomics. Therefore, we conducted a systematic review to identify wearable devices proposed in the scientific literature for ergonomic purposes and analyse how they can support the improvement of ergonomic conditions. Twenty-eight papers were retrieved and analysed thanks to eleven comparison dimensions related to ergonomic factors, purposes, and criteria, populations, application and validation. The majority of the available devices are sensor systems composed of different types and numbers of sensors located in diverse body parts. These solutions also represent the technology most frequently employed for monitoring and reducing the risk of awkward postures. In addition, smartwatches, body-mounted smartphones, insole pressure systems, and vibrotactile feedback interfaces have been developed for evaluating and/or controlling physical loads or postures. The main results and the defined framework of analysis provide an overview of the state of the art of smart wearables in ergonomics, support the selection of the most suitable ones in industrial and non-industrial settings, and suggest future research directions.

Oxygen deficiency hazard in confined spaces in the steel industry: assessment through predictive models.

Objective. In the steel industry, performing activities in confined spaces where potential oxygen displacement can occur may expose workers to fatal consequences. To the best of our knowledge, no quantitative exposure assessment of oxygen deficiency in steel industry confined spaces is available in the literature. To overcome this gap, we performed oxygen deficiency hazard (ODH) assessments in real confined spaces using two existing models to identify the most critical parameters responsible for ODH, and suggest controls for mitigating the asphyxiation risk. Methods. We applied a well-mixed model and a near field-far field approach to estimate the indoor oxygen level with time during and following release of simple asphyxiants. Model inputs were mainly gathered thanks to audits and instrumental tests in three firms. Results. The most severe ODH exposures are posed in spaces with restricted volume and where accidental releases of inert gases can occur. Such exposures can be controlled through early release detections and augmented reality systems. Conclusions. ODH assessments in confined spaces of steel firms allow the identification of the most critical parameters from an oxygen depletion perspective, focusing on which data need careful measurement, and help to establish controls compatible with the operations conducted in these areas.

A multi-criteria methodology for evaluating alternative ultrasound devices.

Several surveys and clinical studies report high prevalence of work-related musculoskeletal disorders (WMSDs) among sonographers and sonologists. Better performing ultrasound devices can increase the number and quality of examinations, but also reduce the user comfort and increase the risk of WMSDs. This should lead the choice of the device to buy and use. To support hospitals or diagnostic centres in selecting the best ultrasound device, this study provides a structured methodology based on a multi-criteria approach, the Analytic Hierarchy Process. It has a Goal (to optimise workers' well-being and satisfy company production objectives) and 45 evaluation elements. It was applied in an Italian hospital comparing 3 alternatives: wireless, portable, and cart-based. The latter proved to be the best in satisfying the Goal, whereas a previous study obtained that the wireless device was preferable considering only the ergonomic point of view. The case study validated the applicability of the methodology. Practitioner summary: This paper provides the decision-makers of hospitals or diagnostic centres with a multi-criteria methodology to select the best ultrasound device capable of optimising workers' well-being and satisfying company production objectives. The methodology can also support manufacturers of ultrasound devices in improving their products. Abbreviations: AHP: analytic hierarchy process; AIUM: American Institute of Ultrasound in Medicine; BSI: British Standards Institution; CEN: European Committee for Standardisation; EU-OSHA: EU Agency for Occupational Safety and Health; ISO: International Organisation for Standardisation; MCMD: multiple criteria decision-making; NIOSH: US National Institute for Occupational Safety and Health; SDMS: society of diagnostic medical sonography; WHO: World Health OrganizationWMSD: work-related musculoskeletal disorder.

Monitoring quality and coverage of harm reduction services for people who use drugs: a consensus study.

BACKGROUND AND AIMS: Despite advances in our knowledge of effective services for people who use drugs over the last decades globally, coverage remains poor in most countries, while quality is often unknown. This paper aims to discuss the historical development of successful epidemiological indicators and to present a framework for extending them with additional indicators of coverage and quality of harm reduction services, for monitoring and evaluation at international, national or subnational levels. The ultimate aim is to improve these services in order to reduce health and social problems among people who use drugs, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection, crime and legal problems, overdose (death) and other morbidity and mortality. METHODS AND RESULTS: The framework was developed collaboratively using consensus methods involving nominal group meetings, review of existing quality standards, repeated email commenting rounds and qualitative analysis of opinions/experiences from a broad range of professionals/experts, including members of civil society and organisations representing people who use drugs. Twelve priority candidate indicators are proposed for opioid agonist therapy (OAT), needle and syringe programmes (NSP) and generic cross-cutting aspects of harm reduction (and potentially other drug) services. Under the specific OAT indicators, priority indicators included 'coverage', 'waiting list time', 'dosage' and 'availability in prisons'. For the specific NSP indicators, the priority indicators included 'coverage', 'number of needles/syringes distributed/collected', 'provision of other drug use paraphernalia' and 'availability in prisons'. Among the generic or cross-cutting indicators the priority indicators were 'infectious diseases counselling and care', 'take away naloxone', 'information on safe use/sex' and 'condoms'. We discuss conditions for the successful development of the suggested indicators and constraints (e.g. funding, ideology). We propose conducting a pilot study to test the feasibility and applicability of the proposed indicators before their scaling up and routine implementation, to evaluate their effectiveness in comparing service coverage and quality across countries. CONCLUSIONS: The establishment of an improved set of validated and internationally agreed upon best practice indicators for monitoring harm reduction service will provide a structural basis for public health and epidemiological studies and support evidence and human rights-based health policies, services and interventions.

Interpersonal Attacks on the Dignity of Members of HIV Key Populations: A Descriptive and Exploratory Study.

Attacks on peoples' dignity help to produce and maintain stigmatization and interpersonal hostility. As part of an effort to develop innovative measures of possible pathways between structural interventions or socially-disruptive Big Events and HIV outbreaks, we developed items to measure dignity denial. These measures were administered to 300 people who inject drugs (PWID), 260 high-risk heterosexuals who do not inject drugs, and 191 men who have sex with men who do not inject drugs (MSM). All of the PWID and many of the high risk heterosexuals and MSM were referred to our study in 2012-2015 by a large New York city study that used respondent-driven sampling; the others were recruited by chain-referral. Members of all three key populations experienced attacks on their dignity fairly often and also reported frequently seeing others' dignity being attacked. Relatives are major sources of dignity attacks. MSM were significantly more likely to report having their dignity attacked by police officers than were the other groups. 40 % or more of each key population reported that dignity attacks are followed "sometimes" or more often both by using more drugs and also by using more alcohol. Dignity attacks and their health effects require more research and creative interventions, some of which might take untraditional forms like social movements.

Developing Measures of Pathways that May Link Macro Social/Structural Changes with HIV Epidemiology.

Macro-social/structural events ("big events") such as wars, disasters, and large-scale changes in policies can affect HIV transmission by making risk behaviors more or less likely or by changing risk contexts. The purpose of this study was to develop new measures to investigate hypothesized pathways between macro-social changes and HIV transmission. We developed novel scales and indexes focused on topics including norms about sex and drug injecting under different conditions, involvement with social groups, helping others, and experiencing denial of dignity. We collected data from 300 people who inject drugs in New York City during 2012-2013. Most investigational measures showed evidence of validity (Pearson correlations with criterion variables range = 0.12-0.71) and reliability (Cronbach's alpha range = 0.62-0.91). Research is needed in different contexts to evaluate whether these measures can be used to better understand HIV outbreaks and help improve social/structural HIV prevention intervention programs.

Some Musings About Big Events and the Past and Future of Drug Use and of HIV and Other Epidemics.

The term "Big Events" began as a way to help understand how wars, transitions and other crises shape long-term HIV epidemiology in affected areas. It directs attention to the roles of ordinary people in shaping these outcomes. Big Events themselves can take years, as in long-term armed struggles like those in Colombia and also long-term political and economic changes like the turn over the last 15 years of many Latin American countries away from neoliberalism and towards attempts to build solidarity economies of some form. The effects of Big Events on HIV epidemics, at least, may run in phases: In the short term, by creating vulnerability to epidemic outbreaks among existing Key Populations like people who inject drugs (PWID) or men who have sex with men (MSM); then, in their non-PWID (or non-MSM) risk networks; and perhaps, several years later, among youth who became involved in high-risk sexual or drug use networks and behaviors due to the social impacts of the Big Event. Issues of time loom large in other articles in this Special Issue as well. Some articles and commentaries in this issue point to another important phenomenon that should be studied more: The positive contributions that people who use drugs and other members of the population make towards helping other people in their communities during and after Big Events. Finally, this Commentary calls for more thought and research about an impending very Big Event, global climate change, and how it may exacerbate HIV, hepatitis C and other epidemics among people who use drugs and other members of their networks and communities.

Theory, measurement and hard times: some issues for HIV/AIDS research.

Economic and political instability and related "big events" are widespread throughout the globe. Although they sometimes lead to epidemic HIV outbreaks, sometimes they do not-and we do not understand why. Current behavioural theories do not adequately address these processes, and thus cannot provide optimal guidance for effective intervention. Based in part on a critique of our prior "pathways" model of big events, we suggest that cultural-historical activity theory (CHAT) may provide a useful framework for HIV research in this area. Using CHAT concepts, we also suggest a number of areas in which new measures should be developed to make such research possible.

De los estudios locales a una perspectiva regional: análisis integrado de datos secundarios en un proyecto colaborativo sobre vulnerabilidades asociadas al uso de drogas en Argentina, Brasil y Uruguay (1998-2004) / From local studies to a regional perspective: pooled analysis of secondary data in a collaborative project on vulnerabilities associated with drug use in Argentina, Brazil and Uruguay (1998-2004)

Este artículo desarrolla los fundamentos metodológicos del diseño de análisis integrado a partir de su empleo para el estudio de situaciones de vulnerabilidad entre usuarios de drogas a nivel regional. Se integraron datos de trece estudios transversales realizados en Argentina, Brasil y Uruguay entre 1998 y 2004. Una revisión crítica del concepto de matriz de datos, que distingue cuatro componentes estructurales, permitió: definir las unidades de análisis abarcando las distintas poblaciones originales; identificar un núcleo común de variables (características sociodemográficas, uso de drogas, prácticas sexuales, serologías de infecciones de transmisión sexual y sanguínea) con sus respectivos valores; examinar los indicadores, las dimensiones y procedimientos empleados para la medición de las variables; y establecer su compatibilidad mediante un análisis comparativo y temático de los instrumentos. Se obtuvo una nueva matriz de 3.534 casos. La colaboración multidisciplinaria entre equipos e instituciones de los tres países hizo posible maximizar las fuentes disponibles para el análisis de características locales y de la región en su conjunto.

This paper develops the methodological principles of pooled analysis design, using it to study situations of vulnerability among drug users at a regional level. Data from thirteen cross-sectional studies carried out in Argentina, Brazil and Uruguay between 1998 and 2004 were integrated. A critical review of the concept of data matrix which identifies four structural components, allowed us to: define the units of analysis spanning the different original populations; identify a core of common variables (social and demographic characteristics, drug use, sexual practices, serology of blood-borne and sexually transmitted diseases) with their respective values; examine the indicators, dimensions and procedures used to measure the variables; and establish their compatibility with a thematic and comparative analysis of data collection tools. The main result was a new data matrix with 3,534 cases. Multidisciplinary collaboration between teams and institutions from the three countries made it possible to maximize the available sources in order to analyze characteristics of the local contexts and of the overall regional.

Has United States drug policy failed? And how could we know?

Discussions of drug policy tend not to consider whether the stated goals of policies are an accurate statement of what they are meant to do and also may not consider the fact that what benefits some people may harm others. We explore these issues and present an agenda for research in this area that, while not eliminating these difficulties, both illuminates them and can help guide actors toward more effective action.

From local studies to a regional perspective: pooled analysis of secondary data in a collaborative project on vulnerabilities associated with drug use in Argentina, Brazil and Uruguay (1998-2004). / De los estudios locales a una perspectiva regional: análisis integrado de datos secundarios en un proyecto colaborativo sobre vulnerabilidades asociadas al uso de drogas en Argentina, Brasil y Uruguay (1998-2004).

This paper develops the methodological principles of pooled analysis design, using it to study situations of vulnerability among drug users at a regional level. Data from thirteen cross-sectional studies carried out in Argentina, Brazil and Uruguay between 1998 and 2004 were integrated. A critical review of the concept of data matrix which identifies four structural components, allowed us to: define the units of analysis spanning the different original populations; identify a core of common variables (social and demographic characteristics, drug use, sexual practices, serology of blood-borne and sexually transmitted diseases) with their respective values; examine the indicators, dimensions and procedures used to measure the variables; and establish their compatibility with a thematic and comparative analysis of data collection tools. The main result was a new data matrix with 3,534 cases. Multidisciplinary collaboration between teams and institutions from the three countries made it possible to maximize the available sources in order to analyze characteristics of the local contexts and of the overall regional.

Este artículo desarrolla los fundamentos metodológicos del diseño de análisis integrado a partir de su empleo para el estudio de situaciones de vulnerabilidad entre usuarios de drogas a nivel regional. Se integraron datos de trece estudios transversales realizados en Argentina, Brasil y Uruguay entre 1998 y 2004. Una revisión crítica del concepto de matriz de datos, que distingue cuatro componentes estructurales, permitió: definir las unidades de análisis abarcando las distintas poblaciones originales; identificar un núcleo común de variables (características sociodemográficas, uso de drogas, prácticas sexuales, serologías de infecciones de transmisión sexual y sanguínea) con sus respectivos valores; examinar los indicadores, las dimensiones y procedimientos empleados para la medición de las variables; y establecer su compatibilidad mediante un análisis comparativo y temático de los instrumentos. Se obtuvo una nueva matriz de 3.534 casos. La colaboración multidisciplinaria entre equipos e instituciones de los tres países hizo posible maximizar las fuentes disponibles para el análisis de características locales y de la región en su conjunto.